GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs41997 | 1 | rs4727865 | chr7:118005595 | ANKRD7 | chr7:117864712-117882782:+ | -0.28 | -4.65 | 4.24E-6 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs41997 | 1 | rs4727867 | chr7:118051152 | ANKRD7 | chr7:117864712-117882782:+ | -0.28 | -4.51 | 8.19E-6 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs4728142 | 1 | rs4728142 | chr7:128573967 | IRF5 | chr7:128577769-128590086:+ | 0.35 | 10.91 | 6.94E-25 | Systemic lupus erythematosus;Ulcerative colitis;Inflammatory bowel disease |
| THCA | cis | rs2157926 | 1 | rs4728709 | chr7:87233602 | DBF4 | chr7:87505544-87538856:+ | 0.23 | 3.52 | 0.00048 | Bone mineral density (spine) and age at menarche |
| THCA | cis | rs6832769 | 1 | rs473005 | chr4:56288125 | TMEM165 | chr4:56262090-56292342:+ | -0.15 | -3.8 | 0.000164 | Personality dimensions |
| THCA | cis | rs4730250 | 1 | rs4730250 | chr7:107207695 | DLD | chr7:107531586-107561642:+ | 0.14 | 3.42 | 0.000676 | Osteoarthritis |
| THCA | cis | rs477692 | 1 | rs473073 | chr10:131429646 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.35 | 1.29E-26 | Response to temozolomide |
| THCA | cis | rs41997 | 1 | rs4730871 | chr7:118079738 | ANKRD7 | chr7:117864712-117882782:+ | -0.27 | -4.41 | 1.28E-5 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs7802263 | 1 | rs4731205 | chr7:124385442 | POT1 | chr7:124462441-124570037:- | 0.15 | 3.42 | 0.000688 | Reading and spelling |
| THCA | cis | rs7112513 | 1 | rs473188 | chr11:116812029 | PCSK7 | chr11:117075789-117102811:- | -0.29 | -5.06 | 5.99E-7 | Protein quantitative trait loci |
| THCA | cis | rs4732038 | 1 | rs4732038 | chr7:134250322 | AKR1B1 | chr7:134127107-134143888:- | 0.21 | 4.49 | 9.09E-6 | Longevity |
| THCA | cis | rs12681963 | 1 | rs4733384 | chr8:29985381 | LEPROTL1 | chr8:29952922-29995222:+ | 0.16 | 3.53 | 0.000464 | Migraine |
| THCA | cis | rs12681963 | 1 | rs4733384 | chr8:29985381 | MBOAT4 | chr8:29989188-30002200:- | 0.4 | 5.24 | 2.47E-7 | Migraine |
| THCA | cis | rs12681963 | 1 | rs4733384 | chr8:29985381 | TMEM66 | chr8:29920632-29940649:- | -0.17 | -3.34 | 0.000902 | Migraine |
| THCA | cis | rs931812 | 1 | rs4734494 | chr8:101917721 | YWHAZ | chr8:101930804-101965623:- | -0.17 | -4.46 | 1.04E-5 | Attention deficit hyperactivity disorder and conduct disorder |